Haemophilia A (factor VIII deficiency / F8)
- Factor VIII deficiency is a type of blood clotting disorder, where affected dogs will bleed spontaneously into their chest, abdomen or joints. They will also develop significant bruising and profuse bleeding after a trauma or surgery. As this condition is sex-linked it means male dogs present this disorder if they have one mutated X-chromosome; the mutation usually comes from the mother. In most examples, the females carry one mutated X chromosome without being affected. Females only are affected when they carry two mutations, coming from both parents. This disorder is usually diagnosed in puppies or young adult dogs but can be diagnosed at any age. Puppies may have abnormal bleeding whilst teething. Other signs are extensive bruising or bleeding after trauma. Where spontaneous bleeding occurs, you may notice swollen joints, difficulty breathing or a drooping abdomen.
- Affected Breeds: Boxer, German shepherd dog, Havana Silk Dog, Havanese, Old English Sheepdog, White Swiss shepherd dog.
Glanzmann’s Thrombastenia (GT):
- GT is a bleeding disorder caused by a dysfunction in blood clotting. There are three types: type 1, type 2 and variant GT. Type 1 is the most severe, variant GT being relatively normal but with reduced function in clotting. Symptoms include prolonged bleeding, severe bruising, red or purple spots under the skin, nose bleeds, bleeding gums, and pin-prick blood spots on the abdomen. This is present from birth, and affected dogs tend to be smaller than the breed average.
- Affected Breeds: Deerhound, Otterhound, Pyrenean Mountain Dog
Haemophilia B (Factor IX deficiency)
- This blood clotting disorder results in a lack of protein factor IX. With the lack of this protein the blood has problems coagulating leading to prolonged bleeding after trauma or surgery, female dogs may also experience issues after whelping. The condition is sex-linked which means male dogs present this disorder if they have one mutated X-chromosome, the mutation usually comes from the mother. In most examples, the females carry one mutated X chromosome without being affected. Females only are affected when they carry two mutations, coming from both parents.
- Affected Breeds:Afghan Hound, Airedale Terrier, Bull Terrier, Cairn Terrier, German Wirehaired Pointer, Lhasa Apso, Rhodesian Ridgeback
Factor VII deficiency (FVIID)
- This is a disorder that affects blood clotting. Due to the lack of Factor VII, dogs affected with this will have prolonged bleeding after surgery or trauma. Clinical signs won’t be evident until a dog has had surgery or an accident where the prolonged bleeding can be noticed.
- Affected Breeds: Airedale Terrier, Alaskan Klee Kai, American Foxhound, Basset Hound, Beagle, Beagle Harrier, Catahoula Leopard Dog, Deerhound, Finnish Hound, German Shorthaired Pointer, German Wirehaired Pointer, Giant Schnauzer, Irish Water Spaniel, Japanese Spitz, Longhaired Dachshund, Miniature Schnauzer, Miniature Longhaired Dachshund, Miniature Smooth haired Dachshund, Miniature Wirehaired Dachshund, Papillion, Schipperke, Sealyham Terrier, Smooth haired Dachshund, Welsh Springer Spaniel, Whippet, Wirehaired Dachshund
von Willebrand disease (vWD)
- Von Willebrand disease is a lack of von Willebrand’s Factor (vWF) a protein that plays a key part in blood clotting. vWD comes in three types: type 1, type 2 and type 3. Type 3 is the most severe and type 1 is the least severe. Dogs with vWD are prone to nose bleeds, bleeding from gums, and prolonged bleeding on heat or after whelping. For puppies there can be prolonged bleeding from the umbilical cord at birth or when teething. vWD suffers commonly have excessive bleeding after surgery or trauma, this could be the first sign of the disease for your dog. Some dogs present with blood in their urine or stool. The effects can widely range between individual dogs with some hardly showing typical signs.
- Affected Breeds Type I: American Hairless Terrier, Australian Cobberdog, Australian Labradoodle, Australian Shepherd, Australian Silky Terrier, Barbet, Basset Hound, Beauceron, Berndoodle, Bernese Mountain Dog, Brazilian Terrier, Cairn Terrier, Cardigan Welsh Corgi, Cockapoo, Coton de Tulear, Dachshunds, Dobermann, Dutch Partridge Dog, Dutch Shepherd, English Toy Terrier, Frisian Pointing Dog, German Pinscher, German Shepherd, Golden Retriever, Goldendoodle, Great Dane, Hungarian Puli, Irish Red And White Setter, Irish Setter, Keeshond, Italian Volpino, Jack Russell Terrier, Kerry Blue Terrier, Kromfohrländer, Maltipoo, Manchester Terrier, Miniature American Shepherd, Miniature Dachshunds, Miniature Poodle, Miniature Schnauzer, Papillon, Pembroke Welsh Corgi, Pomeranian, Portuguese Water Dog, Prague Ratter, Pug, Schipperke, Stabyhoun, Standard Poodle, Rottweiler, Russel Terrier, Toy Manchester Terrier, Toy Poodle, West Highland White Terrier, White Swiss Shepherd Dog.
- Affected Breeds Type II: American Cocker Spaniel, Australian Labradoodle, Australian Stumpy Tail Cattle Dog, Barbet, Boykin Spaniel, Canaan Dog, Chihuahuas, Chinese Crested Dog, Coton de Tulear, Danish-Swedish Farmdog, English Pointer, German Longhaired Pointer, German Shorthaired Pointer, German Spitz, German Wirehaired Pointer, Lagotto Romagnolo, Norwegian Elkhound, Old English Sheepdog, Rough Collie, Smooth Collie, Weimaraner, Xoloitzcuintle
- Affected Breeds Type III: Australian Terrier, Kooikerhondje, Miniature Dachshund, Scottish Terrier, Shetland Sheepdog.
